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Sexual Health

  1. May 20, 2024

    Testosterone Replacement Therapy: Not Just a Guy Thing

    Would it surprise you to know that as far back as 4,000 years ago, intentional castration was used to create eunuchs and control sexual function? What if I told you the ancient Romans ingested animal testes to promote fertility and strength?

    It is apparent that ancient societies understood the effect of testicular function on energy, libido, sexual function, and masculinity. It wasn’t until 40 centuries later, in 1929, that testosterone was first isolated, and four years after that in 1935 that the first studies were published on the chemical synthesis of testosterone. This led to the introduction of testosterone injections and pellets for use in male patients for energy, strength, fertility, and erectile function — what we call testosterone deficiency today.

    Great news for the fellas, but probably not for the ladies, right? Not so fast! As

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  2. April 23, 2024

    The Atlantic: Menopause, estrogen, and women’s unused options

    Women have been dealing with menopause for a couple of hundred thousand years, and yet there’s still a bit of a stigma talking about it, the effects it can have on a woman’s body, and ways to help alleviate some of those negative issues.

    Worse, as this article in the Atlantic explains, many gynecologists will try to solve everything with estrogen (or, if they’re British, oestrogen). Since the 1960s it’s been the go-to magic bullet for women in and after menopause.

    Reality, though, is more complex — and we’ve learned a lot since the ’60s. Still, though, the lack of a “frank approach to sexuality” for both people born female and those who have transitioned there has kept many from realizing the benefits of other hormones. (Ironically, trans women often get better care when it comes to hormones.)

    The point of all this, and of the Atlantic article, is that it’s important for women to think beyond

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  3. January 16, 2024

    Testosterone pellets for male TRT

    The concept of testosterone replacement therapy (TRT) dates back to the early 1900s. Observations of behavioral changes in castrated roosters formed the foundation of what we know to be hypogonadism or “low T.” The concept of “treat like with like” spurred research and by the mid 1930s, testosterone synthesis began. (1)

    During the 1930s, we saw the initiation of TRT with testosterone propionate injections as well as subcutaneous testosterone pellets.(2) By the mid 1940s, researchers had identified multiple indicators of low testosterone including depression, failing memory, increased fatigability, and reduced libido. We now apply that early research, with improved understanding of physiology and the aging process, to successfully treat millions of men who experience the unwanted effects of low testosterone.

    For years, men were prescribed testosterone injections,

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  4. January 12, 2024

    Cause (and cure?) for morning sickness

    Morning sickness is all about the hormones. That part isn’t surprising, but what’s newsworthy is that USC researchers say they’ve discovered exactly which hormone it is — and (potentially) what can be done about it.

    The hormone is called GDF15, and it’s produced by the fetus; it surges in the first trimester.

    “[T]he baby growing in the womb is producing a hormone at levels the mother is not used to. The more sensitive she is to this hormone, the sicker she will become. Knowing this gives us a clue as to how we might prevent this from happening.”

    Some women are especially sensitive to GDF15 and can have morning sickness that requires hospitalization. (Looking at you, Catherine, Princess of Wales.) Other woman have a genetic blood disorder that gives them chronically high levels of GDF15 so they

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